Thanks to former New York City Mayor Tom Cafferty and his team, the villainous Foundation for Human Advancement has been dismantled and the cities of the world are no longer under threat from nuclear annihilation. Cafferty is now on a hunt to decimate every creature on the planet. But when he enters a nest underneath the Nevada desert, he is horrified to find it empty. It can only mean one thing: the battle for survival is not even close to being over. Across the planet, creatures are emerging from their subterranean homes. Now the all-out war against humanity has begun—a war in which only one apex species will survive. Cafferty knows that only one man can help him stop the onslaught—a man despised by the world, who has caused the death of millions, his sworn enemy: Albert Van Ness.